EBV status did not predict failure after nasopharyngeal cancer RT in Denmark
In 331 Danish NPC patients, five-year failure rates were similar by EBV status, while distant relapse was concentrated in locally advanced disease.
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Flap-sparing postoperative RT showed no intraflap recurrences in oral cavity cancer
Among 34 postoperative oral cavity cases, local failures occurred at or near the flap-native interface, with no recurrence inside the flap.
COG highlights major gaps in radiation care for adolescents and young adults
AYA patients face distinct radiation-related late effects and psychosocial challenges, yet age-specific dose constraints and prospective outcome data remain scarce.
Late chest-wall pain affected one-third of patients after breast radiotherapy
Across 5,509 evaluable patients, 34% developed late chest-wall pain, although definitions and reported risk factors varied substantially.
DIBH workflow changes sharply reduced chest-wall motion during breast radiotherapy
Four quality-improvement measures reduced >3-mm chest-wall errors from 21.2% to 4.7%, but sternal marker placement increased skin reactions.
Fractionation mitigated proton interplay for most free-breathing thoracic treatments
Interplay-related underdosage largely disappeared after five fractions, although two high-motion plans retained clinically relevant target deficits.
SRS target location changed pain-response patterns in trigeminal neuralgia
Distal targeting produced more overall pain relief, while proximal targeting yielded more complete pain freedom and medication discontinuation.
Overfilling the bladder made prostate radiotherapy longer and more frustrating
Bladder diameter >10 cm at simulation was associated with longer fractions, more interruptions and greater patient frustration during prostate RT.
Performance status predicted patient-reported toxicity better than age after head and neck RT
Patients aged ≥70 reported similar or lower symptom burden, whereas PS ≥2 consistently predicted worse toxicity and slower recovery after radical RT.
Virtual reality often reduced anxiety and pain during breast cancer care
Across 14 studies, 9 of 11 anxiety studies and 3 of 5 pain studies reported significant improvement with virtual reality.
Two salvage HDR brachytherapy schedules produced similar outcomes in recurrent prostate cancer
In 223 previously irradiated patients, 3×10 Gy and 2×13 Gy salvage HDR brachytherapy produced similar disease control and late toxicity.
SGRT-assisted DIBH reduced heart and LAD dose in left-sided breast radiotherapy
Across 52 studies, SGRT-assisted DIBH reduced mean heart dose by 1.21 Gy and LAD dose by 7.05 Gy versus free breathing.
Postoperative high-dose RT achieved strong local control in lacrimal gland adenoid cystic carcinoma
After surgery plus 66–70 Gy, only one of six patients recurred locally, while half developed distant metastases.
Comorbidity mattered more than chronological age after proton therapy for hepatocellular carcinoma
Age ≥75 did not independently predict outcomes after proton therapy for HCC, while CCI ≥3 was associated with more than threefold higher mortality.
Aggressive concurrent hypofractionation increased fatal toxicity in unresectable stage II–III NSCLC
Across 26 studies, fatal toxicity clustered when BED10 >100 Gy was delivered to the whole tumor with concurrent platinum chemotherapy.